Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising
Completed · Not applicable
Conditions studied: Ecchymosis
In brief
The objective of this study is to assess the comparative utility of topical formulations in hastening the resolution of skin bruising. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser. Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0.3% retinol, 20% arnica or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist rated bruises in standardized photographs immediately after bruise creation and at week 2.
Key facts
- Study ID
- NCT00363038
- Run by
- Northwestern University
- People needed
- 16
- Starts
- 2006-07-01
- Expected to finish
- 2006-08-01
- Last updated by the study team
- 2021-12-03
Who can join
Age: 20 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 20-60
- Subjects are in good health.
- Subjects have willingness and the ability to understand and provide informed consent for participation in the study.
You may not qualify if…
- Subjects who are currently using any anticoagulation therapy (Warfarin, Heparin, Aspirin)
- Subjects who have a history of bleeding disorders.
- Subjects who are unable to understand the protocol or to give informed consent
- Subjects with mental illness
- Subjects who are pregnant or nursing.
- Subjects who have active systemic or local infection
- Subjects with systemic or local skin disease.
- Subjects with systemic illness.
Where it is running
- Northwestern University Feinberg School of Medicine, Department of Dermatology — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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