Elucidation of Acid-Induced Pulmonary Inflammation
Stopped early · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Gastroesophageal Reflux, Asthma
In brief
This study will evaluate how heartburn may lead to different types of inflammation in one's airways. Additionally, the study will determine whether aggressive treatment of heartburn results in improvement in both symptoms of heartburn and asthma but also in documented improvement in airway inflammation as determined by biopsy. The results of this study will be important in directing future research into the relationship between heartburn and asthma and may provide a clue whether certain subtypes of asthma may be caused primarily by gastroesophageal reflux (GER).
Key facts
- Study ID
- NCT00361972
- Run by
- University of Utah
- People needed
- 17
- Starts
- 2006-08-01
- Expected to finish
- 2009-04-01
- Last updated by the study team
- 2016-08-05
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- chronic cough consistent with bronchoreactivity
- Gastroesophageal reflux
You may not qualify if…
- Severe asthmatics who have been hospitalized within the last 6 months or who have required oral steroid use within the last 4 weeks
- Severe coronary artery disease
- Cigarette/cigar smoking within the last 6 months
- Documented allergies affecting the respiratory system
- Subjects with contraindications to pH/impedance probe
- Hemophilia
- Septal deviation
- Subjects with contraindications to bronchoscopy as outlined by the American Thoracic Society Guidelines
- Anticoagulation
- Pregnancy
- Incarcerated patients
- Current oral steroid use (may suppress levels of inflammation)
- Upper respiratory infection within the last 2 weeks
- Ongoing acid suppression with a proton pump inhibitor, however, patients may be included if they have discontinued their proton pump inhibitor within the last 1 month with stable asthma symptoms as defined by stable utilization of inhaled steroids
Where it is running
- University of Utah Health Sciences Center — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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