Diabetes Control and Complications Trial (DCCT)
Completed · Not applicable
Conditions studied: Type 1 Diabetes Mellitus
In brief
Background. Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM). We examined whether intensive treatment with the goal of maintaining blood glucose concentrations close to the normal range could decrease the frequency and severity of these complications. Methods. A total of 1441 patients with IDDM -- 726 with no retinopathy at base line (the primary-prevention cohort) and 715 with mild retinopathy (the secondary-intervention cohort) were randomly assigned to intensive therapy administered either with an external insulin pump or by three or more daily insulin injections and guided by frequent blood glucose monitoring or to conventional therapy with one or two daily insulin injections. The patients were followed for a mean of 6.5 years, and the appearance and progression of retinopathy and other complications were assessed regularly.
Key facts
- Study ID
- NCT00360815
- Run by
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- People needed
- 1441
- Starts
- 1983-08-01
- Expected to finish
- 1993-04-01
- Last updated by the study team
- 2010-03-02
Who can join
Age: 13 and older, up to 39. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California — La Jolla, California, United States
- Yale University School of Medicine — New Haven, Connecticut, United States
- University of South Florida College of Medicine — Tampa, Florida, United States
- Northwestern University — Chicago, Illinois, United States
- DCCT Central Autonomic Coding Unit — Springfield, Illinois, United States
- University of Iowa — Iowa City, Iowa, United States
- University of Maryland — Baltimore, Maryland, United States
- George Washington University, Biostatistics Center — Rockville, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Joslin Diabetes Center, Inc. — Boston, Massachusetts, United States
- University of Michigan, Sattelite-Henry Ford Hospital — Ann Arbor, Michigan, United States
- Henry Ford Hospital — Detroit, Michigan, United States
- International Diabetes Center — Minneapolis, Minnesota, United States
- DCCT Central Nutrition Coding Unit — Minneapolis, Minnesota, United States
- DCCT Central ECG Reading Unit — Minneapolis, Minnesota, United States
- DCCT Central Biochemistry Laboratory — Minneapolis, Minnesota, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Mayo Foundation — Rochester, Minnesota, United States
- Backup DCCT Central HbA1c Lab — Columbia, Missouri, United States
- University of Missouri — Columbia, Missouri, United States
- Washington University at St. Louis — St Louis, Missouri, United States
- University of New Mexico School of Medicine — Albuquerque, New Mexico, United States
- Cornell University Medical College, The New York Hospital — New York, New York, United States
- Albert Einstein College of Medicine — The Bronx, New York, United States
- Case Western Reserve University, Lakeside Hospital — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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