Study to Evaluate Eye Function in Patients Taking Linezolid for Six Weeks or Greater

Stopped early · Phase 3

Conditions studied: Optic Nerve Diseases

In brief

To understand and characterize the effects of linezolid on the optic nerve by observing and following patients who have been treated with linezolid for six weeks or longer for the development of signs or symptoms of visual disturbance or eye disorders.

Key facts

Study ID

NCT00359632

Run by

Pfizer

People needed

34

Starts

2008-11-01

Expected to finish

2013-12-01

Last updated by the study team

2015-06-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female subjects who are 18 years of age or older.
• Subjects in Treated Group:
• Subjects must have received linezolid 600 mg BID for six weeks or greater and be currently on drug (or have received linezolid within 7 days of baseline evaluation).
• Subjects who have current signs or symptoms compatible with linezolid toxicity (i.e. optic or peripheral neuropathy) may be enrolled in the study if they are on linezolid at time of baseline evaluation (or have received linezolid within 7 days of baseline evaluation).
• Linezolid may be discontinued at any time at the primary physician's discretion and remain on the study.
• Women of childbearing potential must use adequate contraception
• Subjects in Control Group:
• Subjects will have a diagnosis similar to patients in the treated group and similar important co-morbidities and epidemiologic factors if possible.

You may not qualify if…

• Subject in Treated Group:
• Subjects with a known presence of optic or peripheral nerve damage due to another illness, condition or medication.
• Subjects with a pre-existing or a diagnosis at time of screening visit of an ophthalmologic condition that would adversely affect the study testing protocol (e.g. dense cataracts, macular degeneration, retinitis pigmentosa).
• Subjects who are currently receiving or anticipated to receive another medication, antibiotic or other, that has known potential to produce ocular or neurologic toxicity indistinguishable from that caused by linezolid or lactic acidosis.
• Subjects with a history of significant exposure, in the opinion of the investigator and with prior discussion with the medical monitor, to medications known to produce optic or peripheral neuropathy.
• Subjects with an active communicable disease (i.e., tuberculosis assessed as currently communicable) and subjects on active treatment for tuberculosis or other mycobacterial disease that include drugs that have known potential to produce ocular or neurologic toxicity.
• Subjects with severe liver disease or abnormal liver function test.
• Subjects in Control Group:
• Subjects must not currently be taking linezolid or have received it for more than 7 days at any time.
• Subjects with a known presence of optic or peripheral nerve damage due to another illness, condition or medication.
• Subjects with a pre-existing or a diagnosis at the screening visit of an ophthalmologic condition that would adversely affect the study testing protocol (e.g. dense cataracts, macular degeneration, retinitis pigmentosa).
• Subjects who are currently receiving another medication, antibiotic or other, that has known potential to produce ocular or neurologic toxicity indistinguishable from that caused by linezolid or lactic acidosis.
• Subjects with a history of significant exposure, in the opinion of the investigator and with prior discussion with the medical monitor, to medications known to produce optic or peripheral neuropathy.
• Subjects with an active communicable disease (i.e., tuberculosis assessed as currently communicable) and subjects on active treatment for tuberculosis or other mycobacterial disease that include drugs that have known potential to produce ocular or neurologic toxicity.

Where it is running

• St. Bernards Research Center — Jonesboro, Arkansas, United States
• Triple O Research Institute, PA — West Palm Beach, Florida, United States
• Ochsner Clinic Foundation — New Orleans, Louisiana, United States
• Henry Ford Health System — Detroit, Michigan, United States
• University of Minnesota, Department of Medicine/Division of Infectious Diseases — Minneapolis, Minnesota, United States
• Drexel University College of Medicine, Partnership Comprehensive Care Practice — Philadelphia, Pennsylvania, United States
• Associates in Infectious Disease and Tropical Medicine — Pittsburgh, Pennsylvania, United States
• Azienda Ospedaliera Universitaria di San Martino — Genova, Italy
• Ospedale San Martino, Clinica Malattie Infettive — Genova, Italy
• Università di Genova — Genova, Italy
• Clinica Malattie Infettive, Azienda Ospedaliero Universitaria Santa Maria della Misericordia — Udine, Italy
• Infektionskliniken 1-73, Karolinska Universitetssjukhuset Huddinge — Stockholm, Sweden

Full record on ClinicalTrials.gov

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