The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

Completed

Conditions studied: Acute Renal Failure, Chronic Kidney Failure, Endothelial Dysfunction, Hemolytic-uremic Syndrome (HUS)

In brief

To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.

Key facts

Study ID

NCT00358306

Run by

University of Alabama at Birmingham

People needed

36

Starts

2008-04-01

Expected to finish

2009-07-01

Last updated by the study team

2020-05-14

Who can join

Age: 2 and older, up to 20. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children between age 2-20
• Decrease in renal function by 25% or greater
• Renal function has returned to normal

You may not qualify if…

• History of chronic disease
• Cancer
• Congenital heart disease
• Organ Transplantation
• Liver disease
• Pulmonary disease
• Diabetes other primary metabolic condition
• Severe neurologic impairments
• Hypertension
• Auto-immune
• Infectious disease or renal disease
• Smokers
• Renal disease w/primary cause i.e. - HUS or Glomerulonephritis
• severe allergies including allergy to seafood and/or iodine

Where it is running

• University Of Alabama — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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