Weaning From Mechanical Ventilation Using Permissive Hypercarbia
Stopped early · Not applicable
Conditions studied: Respiration, Artificial, Respiratory Distress Syndrome, Adult
In brief
Some patients receiving mechanical ventilation have difficulty weaning off the ventilator because of physiological factors such as pre-existing lung disease, respiratory distress syndrome, and trauma among others. Allowing patients to become hypercarbic (increased blood bicarbonate level) may make it easier for these patients to be taken off the ventilator and resume breathing on their own.
Key facts
- Study ID
- NCT00357929
- Run by
- Milton S. Hershey Medical Center
- People needed
- 3
- Starts
- 2006-08-01
- Expected to finish
- 2007-06-14
- Last updated by the study team
- 2017-10-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult (> 18 yo) patients in the intensive care units at the Hershey Medical Center who are on mechanical ventilation
- and whose clinical course permits weaning from mechanical ventilation
- and are felt to have risk factors for difficult weaning. (Risk factors will include patients with rib fractures, pulmonary contusions, obesity (BMI >30), or history of COPD or other significant lung disease.)
- all patients will have failed (rapid shallow breathing index >105) a 30 minute spontaneous breathing test.
You may not qualify if…
- Overt signs of sepsis including: a temperature > 38.5F, white blood cell count > 14000, systolic blood pressure < 100 mmHg,
- intracranial hypertension (ICP > 18 or based upon clinical exam and/or history),
- or pulmonary hypertension (by history or PAsys > 40 mmHg).
- or history of recent(past 6 mos)MI
Where it is running
- Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.