Prevention of Adult Caries Study (PACS)
Completed · Phase 3 · Has a placebo group
Conditions studied: Caries, Dental
In brief
Adult tooth decay is an infectious disease that afflicts the majority of Americans aged 55 and older and is the most common chronic disease at midlife with an ever growing economic toll. Despite the fact that specific bacteria cause tooth decay, no FDA-approved anti-microbial treatment for decay is available to the American dental professional. The Prevention of Adult Caries Study (PACS) is a study designed to evaluate the efficacy of a topical, temporary, 10% w/v chlorhexidine dental coating in reducing new decay in adult dental patients at risk for decay.
Key facts
- Study ID
- NCT00357877
- Run by
- Tufts University
- People needed
- 983
- Starts
- 2006-07-01
- Expected to finish
- 2010-06-01
- Last updated by the study team
- 2017-06-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years of age and older
- at least 20 intact natural teeth, excluding third molars
- 2 or more lesions, of which at least one must be a cavitated D2 or D3
- willing and able to provide informed consent
You may not qualify if…
- pregnant or planning to become pregnant or planning to become pregnant during the study (breastfeeding is permitted)
- use of fixed orthodontic appliances
- allergic to any of the ingredients of the study medication
- long-term antibiotic therapy
- a history of, or currently active, radiation therapy for cancers of the head or neck
- Sjögren's syndrome
- advanced periodontitis
- consumption of the equivalent of more than five servings of acidic or sugared drinks per day
- having 10 or more lesions requiring restorative care at the time of the screening visit
- remineralization therapy within one month of randomization
- investigator discretion
Where it is running
- Tuba City Regional Health Care — Tuba City, Arizona, United States
- Tufts University School of Dental Medicine — Boston, Massachusetts, United States
- Dental Services of Massachusetts — Boston, Massachusetts, United States
- Center for Health Research — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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