Genetic Studies to Identify Stroke Subtypes and Outcome

Completed

Conditions studied: Cerebrovascular Disease, Stroke

In brief

This study will characterize the gene response of the body's immune and inflammatory cells to stroke. There is a wide variation in stroke risk, stroke outcome, and response to clot-busting therapy for stroke. This variation may be due to differences in people's response to injury or infection, or to differences in genetic make-up between individuals. Genes store the biological information that determines the body's response to injury or infection. This study will analyze the activity of a large number of genes to try to learn which genes might be related to patient outcome. This, in turn, may lead to an understanding of which gene profiles are related to increased stroke risk and increased disability or death. Healthy volunteers over age 21 and stroke patients over age 21 who are admitted to the NIH Stroke Program at Suburban Hospital in Bethesda, Md., may be eligible for this study. Volunteers will be screened with a medical history, blood pressure and pulse measurements, electrocardiogram, and neurological examination. Participants will have 20 to 35 milliliters (about an ounce) of blood drawn for genetic studies. The genetic material will be extracted from the white blood cells and analyzed for normal and abnormal gene activity related to stroke. ...

Key facts

Study ID

NCT00357513

Run by

National Institute of Neurological Disorders and Stroke (NINDS)

People needed

840

Starts

2002-06-03

Expected to finish

2008-12-15

Last updated by the study team

2017-07-02

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• HEALTHY VOLUNTEERS:
• Active medical problems
• Current symptomatic infection
• Current severe allergic disorders
• STROKE PATIENTS:
• Cardiovascular instability
• Severe anemia (hemoglobin less than 8.0 gm/dl)
• Hemorrhagic diathesis
• Current infection
• Current severe allergic disorders

Where it is running

• Suburban Hospital — Bethesda, Maryland, United States
• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
• Holy Cross Hospital, Silver Spring — Silver Spring, Maryland, United States

Full record on ClinicalTrials.gov

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