Etoposide, Cyclophosphamide, Thalidomide, Celecoxib, and Fenofibrate in Relapsed or Progressive Cancer
Completed · Phase 2
Conditions studied: Central Nervous System Tumor, Pediatric, Leukemia, Lymphoma, Neuroblastoma, Sarcoma, Unspecified Childhood Solid Tumor, Protocol Specific
In brief
RATIONALE: Drugs used in chemotherapy, such as etoposide and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Thalidomide, celecoxib, and fenofibrate may stop the growth of cancer cells by blocking blood flow to the cancer. Celecoxib also may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving combination chemotherapy together with thalidomide, celecoxib, and fenofibrate may kill more cancer cells. PURPOSE: This phase II trial is studying how well giving etoposide and cyclophosphamide together with thalidomide, celecoxib, and fenofibrate works in treating young patients with relapsed or progressive cancer.
Key facts
- Study ID
- NCT00357500
- Run by
- Dana-Farber Cancer Institute
- People needed
- 101
- Starts
- 2005-01-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2014-10-01
Who can join
Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Connecticut Children's Medical Center — Hartford, Connecticut, United States
- Miami Children's Hospital — Miami, Florida, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- Maine Medical Center Research Institute — Scarborough, Maine, United States
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Children's Hospitals and Clinics of Minnesota - Minneapolis — Minneapolis, Minnesota, United States
- St. Louis Children's Hospital — St Louis, Missouri, United States
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School — New Brunswick, New Jersey, United States
- NYU Cancer Institute at New York University Medical Center — New York, New York, United States
- Hasbro Children's Hospital — Providence, Rhode Island, United States
Full record on ClinicalTrials.gov
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