The Effects of Potassium Citrate on Bone Metabolism
Completed · Phase 4 · Has a placebo group
Conditions studied: Bone Diseases, Metabolic, Osteoporosis, Postmenopausal
In brief
Skeletal buffering of chronic acid loads may contribute to a significant amount of bone loss over time. Evidence from a few small short-term studies suggests that basic compounds, namely potassium citrate and potassium bicarbonate may reduce bone loss and improve bone density. The purpose of this study is to evaluate the effects of potassium citrate on bone metabolism. We hypothesize that administration of potassium citrate to postmenopausal women with osteopenia will reduce bone resorption and improve bone mineral density. Postmenopausal women with osteopenia (T score between -1.0 and -2.5) and no history of fracture will be randomized to either daily potassium citrate or placebo for one year. Primary outcomes will be markers of bone turnover, which will be measured over 12 months. Secondary outcomes will be bone mineral density, compliance, and adverse events.
Key facts
- Study ID
- NCT00357331
- Run by
- Weill Medical College of Cornell University
- People needed
- 83
- Starts
- 2006-08-01
- Expected to finish
- 2011-04-01
- Last updated by the study team
- 2017-06-12
Who can join
Age: 45 and older, up to 75. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Postmenopausal women, more than 2 years post menopause
- Osteopenia, defined as a T score at the lumbar spine or total hip between -1.0 and -2.5
- No history of prior fragility fracture
You may not qualify if…
- Renal insufficiency
- Use of potassium sparing diuretics
- Use of potassium supplements
- Hyperkalemia
- Secondary causes of osteoporosis or metabolic bone disease
- Delayed gastric emptying
- esophageal compression, intestinal obstruction or stricture
- use of anticholinergic medication
- active urinary tract infection.
Where it is running
- Weill Cornell Medical College — New York, New York, United States
Full record on ClinicalTrials.gov
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