Capecitabine and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Nonmetastatic Brain Stem Glioma or High-Grade Glioma
Completed · Phase 1
Conditions studied: Brain and Central Nervous System Tumors
In brief
RATIONALE: Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Capecitabine may make tumor cells more sensitive to radiation therapy. Giving capecitabine together with radiation therapy may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of capecitabine when given together with radiation therapy in treating young patients with newly diagnosed, nonmetastatic brain stem glioma or high-grade glioma.
Key facts
- Study ID
- NCT00357253
- Run by
- Pediatric Brain Tumor Consortium
- People needed
- 24
- Starts
- 2006-01-01
- Expected to finish
- 2010-03-01
- Last updated by the study team
- 2013-01-10
Who can join
Age: 3 and older, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office — Bethesda, Maryland, United States
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Duke Comprehensive Cancer Center — Durham, North Carolina, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
- Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital — Houston, Texas, United States
- Dan L. Duncan Cancer Center at Baylor College of Medicine — Houston, Texas, United States
- Children's Hospital and Regional Medical Center - Seattle — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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