Biological Functions of Carotenoids in Humans
Completed · Not applicable
Conditions studied: Oxidative DNA Damage
In brief
This study will examine the the efficiency fo absorption of major plant pigments, carotenoids, (lutein, beta-carotene and lycopene)and will measure the biological functions of carotenoids in healthy women in response to an 8-week period of carotenoid supplementation. The antioxidant capacity (in both the aqueous and lipid compartments), DNA oxidation (single cell gel electrophoresis), Insulin-like Growth Factor (IGF-1), Insulin-like Growth Factor Binding Protein-3 (IGFBP-3), (gene expression profile (high-density filter-based cDNA microarrays), lipid peroxidation (MDA analysis and Isoprostane determination), and antioxidant nutrient levels (carotenoids, tocopherols, ascorbic acid and uric acid) in the circulation will be measured every other week throughout the study period.
Key facts
- Study ID
- NCT00356252
- Run by
- Tufts University
- People needed
- 40
- Starts
- 2002-04-01
- Expected to finish
- 2003-12-01
- Last updated by the study team
- 2008-07-24
Who can join
Age: 50 and older, up to 70. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- normal hematologic parameters, normal serum albumin, normal liver function, normal kidney function, absence of fat malabsorption and no drug intake which would interfere with fat absorption, metabolism or blood clotting.
You may not qualify if…
- Subjects with a history of kidney stones, active small bowel disease or resection, atrophic gastritis, hyperlipidemia, insulin-requiring diabetes, alcoholism, pancreatic disease, or bleeding disorders. Exogenous hormone users, smokers. Subjects weighing greater than 20% above or below the NHANES median standard.
Where it is running
- Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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