The Ischemia Modified Albumin In Diagnosing Ischemic New Events

Stopped early

Conditions studied: Heart Disease, Ischemic, Ischemia, Myocardial, Ischemic Heart Disease, Unstable Angina

In brief

The purpose of the study is to evaluate the utility of Ischemia Modified Albumin (IMA) for risk stratification in patients presenting with chest discomfort and possible ischemic heart disease, and to evaluate the diagnostic and prognostic implication for IMA for major adverse cardiac events.

Key facts

Study ID

NCT00355992

Run by

Inverness Medical Innovations

People needed

1250

Starts

2006-09-01

Expected to finish

2007-12-01

Last updated by the study team

2009-05-12

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with primary complaints of chest discomfort or patients with symptoms indicative of a moderate to high probability for unstable angina clinically indicated reason for evaluation for ACS in the Emergency Department meeting tyhe following inclusion criteria will be enrolled:
• Age >=21 years
• Presentation within two hours of relief of most recent episode of chest pain or presence of on-going symptoms suggestive of coronary ischemia, which should be at least 10 minutes in duration.
• Patients being evaluated for suspected ischemic signs and or symptoms (chest pain) at the time of presentation according to routine standard of care institutional chest pain protocol/pathway.

You may not qualify if…

• Administration of thrombolytic medication prior to first (presentation) blood draw
• Acute coronary syndrome (ACS) secondary to supply/demand inequity (i.e. known anemia, tachycardia, - defined as HR greater than 150 bpm, known sepsis, hypotension, defined as blood pressure < 90 mmHg).
• Established diagnosis of liver cirrhosis
• Other acute ischemic sources (ongoing severe claudication, mesenteric ischemia, acute TIA/CVA)
• Renal failure requiring dialysis
• Greater than 2 hours from relief of the most recent episode of chest pain or signs and symptoms suggestive of coronary ischemia.
• Chest pain following traumatic injury to the chest
• Evidence for sever systemic infection, manifesting as fever (temperature >100 degrees) and systolic blood pressure <100 mmHg
• Patients unwilling or unable to provide written consent, without available next of kin
• Cocaine-related chest pain
• Pregnancy
• Known diagnosis of active malignancy
• Acute Bowel Ischemia
• Severe peripheral vascular disease
• Acute brain ischemia

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States
• Dartmouth Medical Center — Lebanon, New Hampshire, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• Vanderbilt University — Nashville, Tennessee, United States
• Hamilton General Hospital — Hamilton, Ontario, Canada

Full record on ClinicalTrials.gov

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