High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma

Completed · Phase 3

Conditions studied: Sarcoma

In brief

RATIONALE: Drugs used in chemotherapy, such as vincristine, irinotecan, ifosfamide, etoposide, doxorubicin, cyclophosphamide, and dactinomycin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving high-dose combination chemotherapy together with radiation therapy may kill more tumor cells. PURPOSE: This phase III trial is studying how well giving high-dose combination chemotherapy together with radiation therapy works in treating patients with newly diagnosed metastatic rhabdomyosarcoma or ectomesenchymoma.

Key facts

Study ID

NCT00354744

Run by

Children's Oncology Group

People needed

109

Starts

2006-07-01

Expected to finish

2019-06-30

Last updated by the study team

2020-01-29

Who can join

Age: any, up to 49. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Phoenix Children's Hospital — Phoenix, Arizona, United States
• Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Southern California Permanente Medical Group — Downey, California, United States
• Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
• Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
• Childrens Hospital Los Angeles — Los Angeles, California, United States
• Children's Hospital Central California — Madera, California, United States
• Children's Hospital and Research Center Oakland — Oakland, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Sutter Cancer Center — Sacramento, California, United States
• University of California Davis Cancer Center — Sacramento, California, United States
• Kaiser Permanente Medical Center - Oakland — Sacramento, California, United States
• Rady Children's Hospital - San Diego — San Diego, California, United States
• UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
• Stanford Cancer Center — Stanford, California, United States
• Children's Hospital Center for Cancer and Blood Disorders — Aurora, Colorado, United States
• Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center — Farmington, Connecticut, United States
• Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
• Lombardi Comprehensive Cancer Center at Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• Broward General Medical Center Cancer Center — Fort Lauderdale, Florida, United States
• Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
• Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.