Cyclophosphamide, Antithymocyte Globulin, and Total-Body Irradiation in Treating Patients With Severe Aplastic Anemia Undergoing Umbilical Cord Blood Transplant

Stopped early · Phase 1

Conditions studied: Aplastic Anemia

In brief

RATIONALE: Giving chemotherapy and total-body irradiation before a donor umbilical cord blood stem cell transplant helps stop the growth of abnormal cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving cyclosporine and mycophenolate mofetil before and after transplant may stop this from happening. PURPOSE: This phase I trial is studying the side effects and best dose of total-body irradiation when given together with cyclophosphamide and antithymocyte globulin in treating patients with severe aplastic anemia undergoing umbilical cord blood transplant.

Key facts

Study ID

NCT00354419

Run by

Fred Hutchinson Cancer Center

People needed

30

Starts

2006-02-01

Last updated by the study team

2011-01-05

Who can join

Age: any, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Life-threatening marrow failure of nonmalignant etiology meeting two of the three following criteria: granulocytes < 500/mm\^3; a corrected reticulocyte count < 1%; platelet count < 20,000/mm\^3
• Failure to respond to the best available immunosuppressive treatment protocol by 75 days after initiation of therapy
• Lack of an HLA-identical family member or closely matched (9 or 10 of 10 HLA-locus match) unrelated marrow donor
• DONOR: Unrelated UCB unit matched for at least 4 of 6 loci
• DONOR: Related UCB unit matched for at least 3 of 6 lock
• Selection of the UCB unit(s) will be based upon matching or mismatching at HLA-A, B antigen level and DRB1 allele level typing; while HLA-C antigen/allele and HLA-DQB1 antigen/allele level typing are not considered in the matching criteria, if available each may be used to optimize unit selection
• Multiple UCB units are allowed to provide sufficient cell dose; when multiple units are selected, the following rules apply: a) the UCB unit with the least HLA disparity will be selected first (i.e., selection priority is 6/6 match > 5/6 match > 4/6 match), additional UCB units may be selected to increase cell dose; b) UCB units must be matched to each other for at least 4 of 6 loci; c) each unit must contain at least 1.5 x 10\^7 Total Nucleated Cells per kg recipient weight; d) the total cell dose of the combined units must be at least 3.0 x 10\^7 Total Nucleated Cells per kg recipient weight

You may not qualify if…

• Severe disease other than aplastic anemia that would severely limit the probability of survival during the graft procedure; patients who present with active fungal infections must be treated to resolve this problem before beginning the conditioning regimen
• HIV seropositive patients
• Patients who have developed clonal cytogenetic abnormalities or a myelodysplastic syndrome (these patients will be considered in separate protocols for myelodysplastic syndrome, etc.)
• Patients with paroxysmal nocturnal hemoglobinuria or Fanconi anemia
• Patients > 40 years of age
• Related or unrelated cord blood units with < 1.5 x 10\^7 Total Nucleated Cells per kg recipient weight
• Related or unrelated cord blood units without full testing and negative results for hepatitis A, B, C, HIV, HTLV-1, CMV viruses

Where it is running

• Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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