Genetic Analysis of African-Americans With High Blood Pressure

Completed

Conditions studied: Hypertension

In brief

The purpose of this study is to learn if kinase, a protein found in the heart, contributes to thickening of the heart muscle in people with high blood pressure. A protein called myosin causes the heart to contract and relax. It is thought that kinase changes myosin to make it work better at different heart rates. This study will try to determine if, in some people with high blood pressure, the different forms of this protein cause changes in the heart. If the protein affects the size of the heart, it might be possible to use it to improve heart function after an injury, such as a heart attack. African-Americans with high blood pressure will be eligible for this study. Current data show that of almost 900 multi-ethnic individuals, the particular form of kinase under study in this project is found exclusively in the African-American population. Study participants will have two tubes of blood drawn for DNA testing to determine what form of kinase is present. An electrocardiogram will also be done if a recent one is not available. Some people may also have an echocardiogram, an ultrasound test to image the heart.

Key facts

Study ID

NCT00353925

Run by

National Heart, Lung, and Blood Institute (NHLBI)

People needed

1000

Starts

1999-10-05

Expected to finish

2007-12-10

Last updated by the study team

2017-07-02

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• For subjects with Kinase Allele:
• There will be no exclusion criteria. Patients will be evaluated even if they are only able to participate in part of the study.
• For Subjects without the kinase allele and Myopathy Cohort:
• History of myocardial infarction
• History of significant valve disease
• History of primary hyperthropic or infiltrative cardiomyopathy
• History of rheumatic heart disease
• Chronic atrial arrhythmia, bundle branch block intraventricular conduction defect or definite myocardial infarction on EKG
• Inability to perform a metabolic stress test
• Inability to perform a cMRI
• Poor echocardiographic windows precluding accurate analysis

Where it is running

• University of Maryland, Baltimore — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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