Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension
Completed · Phase 4
Conditions studied: Hypertension
In brief
Thiazide medications are often prescribed for individuals with high blood pressure, but research has shown that they may increase an individual's risk of developing diabetes. While it is unknown exactly how thiazide causes this response, it is likely that the nervous system is somehow involved. This study will evaluate the role of the nervous system in sugar metabolism, as well as determine the effect of thiazide and other medications on individuals with high blood pressure.
Key facts
- Study ID
- NCT00353652
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 166
- Starts
- 2005-01-01
- Expected to finish
- 2013-01-01
- Last updated by the study team
- 2019-02-06
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Untreated stage 1 primary hypertension (systolic blood pressure between 140 to 159 mm Hg and diastolic blood pressure between 90 to 99 mm Hg)
You may not qualify if…
- Cardiopulmonary disease, as determined by medical history or by physical examination
- Serum creatinine greater than or equal to 1.5 mg/dL
- Diabetes mellitus or other systemic illness
- Left ventricular hypertrophy by echocardiography or ECG
- Hypersensitivity to chlorthalidone, spironolactone, eplerenone, angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blocker, insulin, Evans blue dye, or clonidine
- History of substance abuse (other than tobacco)
- History of gouty arthritis
- History of ACE inhibitor-induced cough or angioedema
- Evidence of secondary hypertension
- Pregnant
Where it is running
- University of Texas Southwestern Medical Center at Dallas — Dallas, Texas, United States
- University of Texas Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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