Telomere Repair Gene Mutation in Inflammatory Bowel Disease

Completed

Conditions studied: Inflammatory Bowel Disease

In brief

This study will evaluate and compare the genes of the telomere repair complex in healthy control subjects, patients with blood diseases, and patients with inflammatory bowel disease to identify what, if any, changes are associated specifically with inflammatory bowel disease. Patients between 2 and 80 years of age with ulcerative colitis or regional enteritis may be eligible for this study. Participants are recruited from the practice of Dr. Stuart Danovitch, Washington, D.C. Researchers have established that minor differences in a specific set of genes called the telomere repair complex are related to immune-mediated diseases of the bone marrow. NIH researchers are now interested in whether inflammatory bowel disease and other autoimmune diseases show a similar pattern of genetic differences. Participants provide a cell sample for evaluation of the telomere repair complex. The sample is collected via buccal swab, a gentle scraping of the inside of the cheek, and stored for use in research.

Key facts

Study ID
NCT00353639
Run by
National Heart, Lung, and Blood Institute (NHLBI)
People needed
95
Starts
2006-05-15
Expected to finish
2020-05-21
Last updated by the study team
2020-05-22

Who can join

Age: 2 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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