Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium

Completed · Phase 2

Conditions studied: Delirium, Agitation

In brief

The purpose of the research is to see if dexmedetomidine (a drug that has a calming effect - a sedative) is effective for the treatment of acute delirium

Key facts

Study ID

NCT00351299

Run by

Brigham and Women's Hospital

People needed

53

Starts

2006-01-01

Expected to finish

2012-10-01

Last updated by the study team

2017-06-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults admitted to our surgical ICU who do not have any exclusion criteria
• Eligibility for treatment- Development of delirium as defined

You may not qualify if…

• Acute MI (myocardial infarction),
• Trauma <24 hours,
• Head injury,
• Multiple organ failure,
• EF (ejection fraction) < 30%,
• History of hypersensitivity to alpha2 agonist,
• History of seizures, MAP (mean arterial pressure) <60 mm of Hg,
• Dysrhythmias a/with bradycardia (HR (heart rate) <50),
• Need for vasopressors,
• Acute renal failure with a need for dialysis/CVVH (Continuous Veno-Venous Hemofiltration) or liver disease.
• Women of child bearing age who do not have a documented negative pregnancy test and/or who do not actively use contraception. (Documented negative pregnancy test will be a urine pregnancy test obtained on this admission)

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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