Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria

Completed · Phase 3 · Has a placebo group

Conditions studied: Arthritis, Reactive, Reiter Disease

In brief

Reactive arthritis, also known as Reiter's syndrome, is a form of arthritis that occurs as a reaction to an infection elsewhere in the body. It is characterized by inflammation of the joints, tendons, urogenital tract, and eyes. Pain and swelling in the knees, ankles, and feet are common. This study will determine the effectiveness of antibiotic therapy in treating people with chlamydia-induced reactive arthritis that has lasted for more than 6 months.

Key facts

Study ID

NCT00351273

Run by

University of South Florida

People needed

42

Starts

2006-05-01

Expected to finish

2008-09-01

Last updated by the study team

2018-11-13

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet the following European Spondyloarthropathy Study Group Criteria:
• inflammatory spinal pain OR
• synovitis AND
• one or more of the following:
• positive family history
• urethritis or cervicitis within 1 month prior to onset of arthritis
• buttock pain
• enthesopathy
• sacroiliitis
• Disease duration of at least 6 months
• Negative pregnancy test at study baseline and willing to use an effective method of contraception other than combined oral contraceptives for the duration of the study (for women of childbearing age)

You may not qualify if…

• Sensitivity or history of allergic reaction to rifampin, doxycycline, or azithromycin
• Currently taking any medications that may interact with the study medications, specifically rifampin
• Liver transaminases greater than or equal to two times the normal level
• Significant abnormalities in the complete blood count (CBC)
• Pregnant
• Current psoriasis
• Diagnosis of inflammatory bowel disease
• Diagnosis of ankylosing spondylitis
• Previous prolonged exposure to antibiotics (more than 2 weeks) as a potential treatment for reactive arthritis

Where it is running

• University of South Florida — Tampa, Florida, United States
• Louisiana State University — New Orleans, Louisiana, United States
• University of Toronto — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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