Cognitive Therapy for Negative Symptoms and Functioning

Completed · Phase 2

Conditions studied: Schizophrenia, Schizoaffective Disorder

In brief

This clinical trial tests the effectiveness of cognitive therapy (CT) to improve outcomes in outpatients diagnosed with schizophrenia or schizoaffective disorder who manifest prominent negative symptoms. It is hypothesized that patients receiving cognitive therapy will manifest lower negative symptom levels and improved engagement in constructive activity relative to patients who receive treatment-as-usual. Further, it is predicted that these differences between CT and TAU will be larger when patients are assessed 6 and 12 months after the end of treatment (18 and 24 months after study entry).

Key facts

Study ID

NCT00350883

Run by

University of Pennsylvania

People needed

61

Starts

2006-07-01

Expected to finish

2011-11-01

Last updated by the study team

2012-05-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Outpatient diagnosed with schizophrenia or schizoaffective disorder
• Prominent negative symptoms (i.e., two global subscales rated "moderate" or higher on the Scale for the Assessment of Negative Symptoms
• Proficiency in English
• Able to give informed consent

You may not qualify if…

• Neurologic disease or damage
• Systematic medical illnesses that may compromise neurocognitive functioning (e.g., insulin dependent diabetes, heart disease)
• History of head injury or documented loss of consciousness
• Physical handicaps that would interfere with assessment procedures

Where it is running

• Psychopathology Resarch Unit, Department of Psychiatry, University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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