Masked Faces in Parkinson Disease: Mechanism and Treatment

Completed · Phase 2 · Has a placebo group

Conditions studied: Parkinson's Disease

In brief

The purpose of this study is to examine the effectiveness of high intensity respiratory muscle strength training in treating blunted facial expression in people with Parkinson disease.

Key facts

Study ID

NCT00350402

Run by

University of Florida

People needed

44

Starts

2004-12-01

Expected to finish

2009-11-01

Last updated by the study team

2012-04-06

Who can join

Age: 45 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A clinical diagnosis of idiopathic Parkinson disease
• Hoeh-Yahr Stage 1-3 when off medication
• Stable and optimal medical regimen for at least 3 months
• No previous surgical interventions for Parkinson's disease (i.e., deep brain stimulation, pallidotomy, stem cell implantation)
• Participants will include men and women between the ages of 45 and 80 years

You may not qualify if…

• Evidence of dementia based on neurocognitive testing
• Current or past history of major psychiatric disturbance (e.g., schizophrenia, bipolar disorder, substance abuse). Participants who are taking anti-depressants will not be excluded as long as they are not currently depressed (Beck Depression, SCID)
• Other neurologic disturbance (e.g., tumor, stroke, traumatic brain injury, epilepsy) or severe chronic medical illness (e.g., HIV, metastatic cancer)
• Presence of oro-facial dyskinesias
• Previous surgeries to the larynx that result in poor vocal fold closure and/or positive history of head and neck cancer
• History of smoking in the past 5 years
• Untreated hypertension
• Failing a baseline test of pulmonary function during baseline respiratory evaluation
• Known respiratory complications such as chronic obstructive pulmonary disease (POCD), asthma
• Previous surgical interventions for Parkinson's disease (i.e., deep brain stimulation, pallidotomy, stem cell implantation)

Where it is running

• Cognitive Neuroscience Laboratory, L3-135, McKnight Brain Institute, University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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