Clinical Trial of Dipyridamole in Schizophrenia
Completed · Not applicable
Conditions studied: Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
In brief
This is a 6-week, randomized, double blind, parallel groups designed, olanzapine-controlled trial of oral dipyridamole in symptomatic patients with a (DSM IV) diagnosis of schizophrenia, schizoaffective or schizophreniform disorder. This pilot study aims to provide preliminary estimates of whether the effect sizes of dipyridamole on positive symptoms, negative symptoms, and cognitive deficits differ between schizophrenia patients treated with dipyridamole, and schizophrenia patients treated with olanzapine. A total of 30 subjects will be recruited locally.
Key facts
- Study ID
- NCT00349973
- Run by
- University of Maryland, Baltimore
- People needed
- 29
- Starts
- 2001-05-01
- Expected to finish
- 2011-09-01
- Last updated by the study team
- 2019-11-04
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects between ages 18-65, both males and nonpregnant females (on birth control) Diagnosis of schizophrenia, schizoaffective or schizophreniform disorder Ability to give written informed consent Total BPRS score > 27 Psychosis subscale scores > 7
You may not qualify if…
- Patients with coagulative disorders, bleeding diathesis or currently on anticoagulants, and patients with major medical illnesses (including hypertension, angina, and cardiovascular diseases) or an abnormal baseline ECG.
- Patients with moderate to severe mental retardation.
- Inability to sign informed consent.
- Patients with a history of serious violence (e.g., suicide attempts, or assaultive behavior).
- Patients on clozapine treatment within the 6 weeks leading to the double-blind phase.
- Patients with a history of olanzapine non-response
- Positive Urine Toxicology Screen
Where it is running
- Maryland Psychiatric Research Center — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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