Clinical Trial Ceftriaxone in Subjects With ALS

Completed · Phase 3 · Has a placebo group

Conditions studied: Amyotrophic Lateral Sclerosis, ALS

In brief

The purpose of the study is to evaluate the safety and efficacy of ceftriaxone treatment in amyotrophic lateral sclerosis (ALS).

Key facts

Study ID

NCT00349622

Run by

Massachusetts General Hospital

People needed

513

Starts

2006-07-01

Expected to finish

2012-11-01

Last updated by the study team

2014-04-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants will be people with ALS, at least 18 years of age.
• Participants must be medically able to undergo the study procedures and have a caregiver or other individual who will be available to help with daily study medication administration.
• Participants should live within a reasonable distance of the study site, due to frequent study visits.

You may not qualify if…

• Participants cannot be taking any other experimental medications for ALS, or have a history of sensitivity to cephalosporin antibiotics (such as Ancef, Keflex, Ceclor, Ceftin, Lorabid, Suprax, or Fortaz).

Where it is running

• University of California, Davis — Davis, California, United States
• University of California, San Francisco- Fresno — Fresno, California, United States
• Loma Linda University School of Medicine (CA) — Loma Linda, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• University of California, Los Angeles — Los Angeles, California, United States
• University of California, Irvine - MDA ALS Neuromuscular Center — Orange, California, United States
• California Pacific Medical Center — San Francisco, California, United States
• University of California, San Francisco — San Francisco, California, United States
• University of Colorado Health Sciences Center — Aurora, Colorado, United States
• Hospital for Special Care — New Britain, Connecticut, United States
• George Washington University — Washington D.C., District of Columbia, United States
• Mayo Clinic Jacksonville — Jacksonville, Florida, United States
• University of Miami School of Medicine — Miami, Florida, United States
• ALS Center at Emory University — Atlanta, Georgia, United States
• Medical College of Georgia — Augusta, Georgia, United States
• Northwestern University Medical School — Chicago, Illinois, United States
• Indiana University (Regenstrief Health Center) — Indianapolis, Indiana, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Kentucky Medical Center — Lexington, Kentucky, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Lahey Clinic — Burlington, Massachusetts, United States
• Henry Ford Health System — Detroit, Michigan, United States
• Saint Mary's Healthcare — Grand Rapids, Michigan, United States
• Hennepin County Medical Center (Berman Center) — Minneapolis, Minnesota, United States
• Phoenix Neurological Associates — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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