Dietary Supplements for the Treatment of Angelman Syndrome

Completed · Not applicable

Conditions studied: Angelman Syndrome, Nervous System Diseases

In brief

Angelman syndrome (AS) is a complex genetic disorder that affects the nervous system. The purpose of this study is to determine the effectiveness of certain dietary supplements in treating the symptoms of AS.

Key facts

Study ID

NCT00348933

Run by

University of California, San Diego

People needed

90

Starts

2006-07-01

Expected to finish

2010-02-01

Last updated by the study team

2012-09-24

Who can join

Age: 0 and older, up to 5. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of AS
• In stable condition with relatively good control of seizures
• Willing to comply with treatment, study visit schedule, and study assessments
• Willing to take oral or G-tube medication
• Willing to be contacted monthly during the course of the study
• Parent or guardian willing to provide informed consent

You may not qualify if…

• History of liver or kidney disease
• Currently being treated for a serious acute illness
• Known hypersensitivity to any of the study drugs
• Received high-dose folate drug treatment in the 12 months prior to study entry
• Other significant medical problems, including those involving the liver, kidney, or heart
• Other comorbidities, genetic disorders, or extreme prematurity; children with autism are not excluded

Where it is running

• Rady Children's Hospital San Diego — San Diego, California, United States
• Children's Hospital Boston — Boston, Massachusetts, United States
• Greenwood Genetics Center — Greenwood, South Carolina, United States
• Baylor College of Medicine — Houston, Texas, United States

Full record on ClinicalTrials.gov

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