A Study of Computed Tomography (CT) for Evaluation of Coronary Artery Blockages in Typical or Atypical Chest Pain

Completed · Not applicable

Conditions studied: Coronary Artery Disease

In brief

To compare computed tomography (CT) images (pictures) of the coronary arteries using the General Electric (GE) LightSpeed VCT scanner with x-ray coronary angiography in patients with typical or atypical chest pain suspected of coronary artery disease (CAD).

Key facts

Study ID

NCT00348569

Run by

GE Healthcare

People needed

245

Starts

2006-05-01

Expected to finish

2007-01-31

Last updated by the study team

2019-04-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The subject has typical or atypical chest pain suspected of CAD and is referred for an elective coronary angiography.
• The subject must be scheduled to undergo a CATH procedure between 48 hours and 3 weeks post CCTA procedure.
• The subject must not undergo any cardiac interventional treatment between the 2 procedures.
• The subject must have sinus rhythm with stable heart rate of ≤65 beats per minute (bpm) or if heart rate was >65 bpm, the subject must agree to the use of beta-blocker(s) prior to the CT scan procedure to achieve stable heart rate of ≤65 bpm.

You may not qualify if…

• The subject had an established diagnosis of CAD by a) previous CATH, b) prior myocardial infarction confirmed by ECG, or c) prior revascularization (balloon angioplasty, stent placement, or CABG).
• The subject had a known allergy to iodinated contrast agent, including but not limited to hives, anaphylactoid or cardiovascular reactions, laryngeal edema and bronchospasm.
• The subject had impaired renal function with a serum creatinine level of 1.7 mg/dL (150 μmol/L) or above.
• The subject had atrial fibrillation/flutter or any irregular heart rhythm considered by the investigator to interfere with temporal acquisition of cardiac CT images.
• The subject had a resting heart rate of >100 bpm and/or a resting systolic blood pressure of <100mm Hg.
• The subject had an artificial heart valve(s).
• The subject has had prior pacemaker or internal defibrillator lead implantation.
• The subject's resting heart rate was >65 bpm and beta-blocker therapy was contraindicated.
• The subject had a contraindication to verapamil when beta-blocker therapy could not be administered. The subject had a contraindication to nitroglycerin.
• The subject had evidence of ongoing or active clinical instability.

Where it is running

• Robert Centofanti, MS — Princeton, New Jersey, United States

Full record on ClinicalTrials.gov

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