Magnesium Supplementation to Prevent Bone Loss
Completed · Phase 1
Conditions studied: Osteoporosis
In brief
Extreme magnesium deficiency is known to have an impact on the synthesis, secretion and/or action of calcium regulating hormones. Many older adults are at risk for less severe magnesium deficiency, since the majority of adults receive less than the Recommended Daily Allowance of magnesium. We hypothesize that magnesium supplementation will have a beneficial effect on calcium regulating hormones and markers of bone turnover.
Key facts
- Study ID
- NCT00346658
- Run by
- University of Tennessee
- People needed
- 74
- Starts
- 2002-07-01
- Expected to finish
- 2006-09-01
- Last updated by the study team
- 2008-12-15
Who can join
Age: 55 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy ambulatory men and women between the ages of 55-75 years
- Women at least 5 years after menopause
You may not qualify if…
- Inability to give informed consent in accordance with institutional guidelines
- Creatinine greater than or equal to 2 mg/dl, since magnesium is excreted by the kidneys
- Diarrhea or loose frequent stools (> 2 a day) at least 3 days/ week in last 3 months
- Use within 12 months of estrogen, bisphosphonates, calcitonin, or raloxifene
- Current use of loop diuretics
- Use within 12 months of corticosteroids
- History of hyperparathyroidism, hyperthyroidism, or osteomalacia within past 12 month
- Vitamin D deficient as measured by 25-hydroxyvitamin D outside of the normal range
- Magnesium supplementation of greater than 250 mg/day
- Calcium supplementation of greater than 1500 mg/day
- Conditions which, in the opinion of the investigator, would interfere with the evaluation of BMD at the spine including severe scoliosis, osteophytosis and lumbar fusion
- Bilateral hip replacement
- BMD at the lumbar spine L2-L4 of less than 0.859g/cm2 for women or 0.895 g/cm2 in men; or total hip less than 0.698 g/cm2 for women or 0.731 g/cm2 for men; or femoral neck less than 0.627 g/cm2 for women or 0.658 g/cm2 for men This represents a T-score of less than -2 at each site
- High serum calcium on screening blood test
Where it is running
- University of Tennessee Health Sciences Center — Memphis, Tennessee, United States
Full record on ClinicalTrials.gov
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