Biliary Atresia Study in Infants and Children

Recruiting now

Conditions studied: Biliary Atresia

In brief

Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following aims: To identify the gene or genes implicated in the etiology of BA; To characterize the natural history of the older, non-transplanted child with BA.

Key facts

Study ID

NCT00345553

Run by

Arbor Research Collaborative for Health

People needed

1265

Starts

2006-05-16

Expected to finish

2029-05-31

Last updated by the study team

2026-06-04

Who can join

Age: 1 and older, up to 20. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants need to have a confirmed diagnosis of BA determined by chart review including review of pertinent diagnostic biopsy reports, radiologic reports and surgical reports (if surgery was performed).
• Participants need to be >6 months of age up to and equal to the age of 20 (participants enrolled at 20 years of age will have one visit).
• Participants with their native liver.
• Parent, guardian or participant (if 18 years of age or older) is willing to provide informed consent and, when appropriate, the participant is willing to assent.

You may not qualify if…

• Currently participating in the ChiLDReN study PROBE.
• Inability to confirm original diagnostic evaluation of biliary atresia.
• Inability or unwillingness of family or participant to participate in all scheduled visits.
• History of liver transplantation.

Where it is running

• Children's Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
• Children's Healthcare of Atlanta - Emory University — Atlanta, Georgia, United States (enrolling)
• Texas Children's Hospital (Baylor College of Medicine) — Houston, Texas, United States (enrolling)
• University of Utah — Salt Lake City, Utah, United States (enrolling)
• Seattle Children's Hospital — Seattle, Washington, United States (enrolling)
• Children's Hospital of Los Angeles — Los Angeles, California, United States (enrolling)
• Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States (enrolling)
• Children's Hospital Colorado — Aurora, Colorado, United States (enrolling)
• Hospital for Sick Children — Toronto, Ontario, Canada
• University of California at San Francisco — San Francisco, California, United States
• Riley Children's Hospital — Indianapolis, Indiana, United States
• Johns Hopkins School of Medicine — Baltimore, Maryland, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Mount Sinai Medical Center — New York, New York, United States
• UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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