Transplantation of Tissue Cultured Human Amniotic Epithelial Cells Onto Damaged Ocular Surfaces

Withdrawn before enrolling · Not applicable

Conditions studied: Corneal Epithelial Dystrophy

In brief

To investigate the effect of using tissue cultured human amniotic epithelial cells to re-establish severely damaged ocular surfaces. Specifically, to determine the efficacy of transplanted tissue cultured amniotic epithelial cells on persistent corneal epithelial defect, a potential visual threaten ocular disorder.

Key facts

Study ID: NCT00344708
Run by: University of Texas Southwestern Medical Center
People needed: 0
Starts: 2000-09-01
Expected to finish: 2010-04-01
Last updated by the study team: 2018-08-22

Who can join

Age: 18 and older, up to 88. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Patients with corneal epithelial defects and ulcers that have persisted for 4 weeks or longer, regardless of their cause. These patients will have received traditional medical therapy, including correcting the underlying causes, suppressing inflammation, and augmenting the tissue healing processes, but the epithelial defects have persisted.

You may not qualify if…

Patients who are pregnant or under age 18 will be excluded.
Placentas will not be used if the following problems are present:
If the mother has an infection at the time of her baby's birth;
If the mother has a high risk of developing infection due to intravenous drug use or other factors;
If the mother has diabetes, arthritis, or raised blood pressure;
If the baby is unhealthy;
If there is evidence of infection of the womb (uterus) and afterbirth (placenta) at the time of delivery.

Where it is running

Aston Ambulatory Care Center — Dallas, Texas, United States
University of Texas Southwestern Medical Center at Dallas — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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