Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients

Completed · Phase 2 · Has a placebo group

Conditions studied: Alcoholism

In brief

The purpose of the study will be to evaluate the efficacy of mecamylamine in reducing alcohol consumption in smoking and non-smoking alcohol dependent patients. We hypothesize that mecamylamine will result in a greater reduction of alcohol consumption than placebo. We further hypothesize that mecamylamine will be effective in reducing both alcohol consumption and smoking in a subset of alcoholics who also smoke.

Key facts

Study ID

NCT00342563

Run by

Yale University

People needed

136

Starts

2004-05-01

Expected to finish

2015-07-01

Last updated by the study team

2019-06-04

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• individuals with DSM-IV diagnosis of alcohol dependence
• smokers and non-smokers
• patients who do not require psychotropic medication for the management of their psychiatric symptoms
• individuals with a history of substance dependence (other than alcohol and tobacco) but have not met criteria for substance dependence in the past 30 days
• women with acceptable method of contraception

You may not qualify if…

• pregnant women
• medications thought to influence drinking behavior including: acamprosate, disulfiram, naltrexone and ondansetron
• underlying medical conditions
• history of glaucoma, prostatic hypertrophy, urethral obstruction, cerebral arteriosclerosis, pyloric stenosis, or a history of hypersensitivity to mecamylamine
• DSM-IV diagnosis of bipolar disorder, schizophrenia, and schizophrenia-type disorders
• unstable medical conditions
• patients who require psychotropic medication for the management of an active psychiatric disorder
• patients on pharmacological treatment for alcohol and/or nicotine dependence

Where it is running

• VA Connecticut Healthcare System — West Haven, Connecticut, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.