In Vitro Study of Peripheral Blood Mononuclear Cell Function in Healthy Individuals and Patients

Completed

Conditions studied: Cell Function

In brief

Peripheral blood mononuclear cells (PBMC) will be collected from healthy volunteers and patients who present with different diseases that involve or implicate the immune system dysregulation (HIV infection, autoimmune diseases and cancer). These PBMC will be studied in vitro for a number of functional parameters, including generating soluable factors that inhibit HIV infection, developing patterns of immune dysregulation, and inducing apoptotic T cell death. The purpose of such studies is to obtain insight into the mechanisms of natural resistance to viral infections, AIDS pathogenesis, and disease-induced immune dysregulation.

Key facts

Study ID

NCT00342485

Run by

National Cancer Institute (NCI)

People needed

5000

Starts

1993-04-12

Expected to finish

2008-03-03

Last updated by the study team

2017-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Unable to provide informed consent.
• Unable to meet the minimum (150 days) and maximum (395 days) research visit interval requirements.

Where it is running

• Willford Hall USAF Medical Center — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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