Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human Parturition

Completed

Conditions studied: Preterm Birth, Premature Rupture of Membranes

In brief

The understanding of the biological mechanisms underlying preterm birth is very limited, making prevention of preterm birth difficult. The incidence of preterm birth worldwide varies between 6%-11% in singleton pregnancies, and 64-93% of preterm deliveries occur after the spontaneous onset of labor (preterm labor). The risk factors associated with preterm birth include demographic variables such as ethnic group, past obstetric history, and complications of the current pregnancy such as infection and fetal congenital anomalies. The current study aims to investigate the basic mechanisms of preterm labor by systematically cataloging the changes in expression levels of all expressed genes whose sequences are available. The goals will be accomplished by using microarray technology followed by subsequent confirmative or complementary analyses.

Key facts

Study ID

NCT00342277

Run by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

People needed

6838

Starts

1999-12-21

Expected to finish

2016-05-05

Last updated by the study team

2023-02-24

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Refusal of written informed consent
• Fetal or maternal conditions mandating immediate delivery (i.e. fetal distress, significant hemorrhage, etc.)

Where it is running

• Wayne State University — Detroit, Michigan, United States
• Sotero del Rio Hospital — Puente Alto, Chile
• Padova Hospital — Padova, Italy
• Seoul National University — Seoul, South Korea

Full record on ClinicalTrials.gov

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