Interdisciplinary Case-Control Study of Non-Hodgkin's Lymphoma

Completed

Conditions studied: Non-Hodgkin's Lymphoma

In brief

Non-Hodgkin's lymphoma (NHL) incidence rates have risen three percent per year in the U.S. for four decades. Mortality from NHL has risen 1.6 percent, compared with 0.2 percent for all cancers combined. This epidemic curve appears in both sexes and around the world, suggesting the possibility of an etiologic agent increasing in prevalence in the general environment. Recent research has identified several possible candidates including pesticides, other organochlorines, drinking water nitrates, and sunlight. There is an urgent need to evaluate whether these common exposures are contributing to the rapid rise in NHL, and to investigate other hypothesized risk factors such as viruses, medical conditions, hair dye use, and genetic factors. The purpose of this study is to examine the contribution to NHL risk of these important environmental, occupational, viral, medical, and personal exposures, and to pursue important leads emerging from on-going NHL research. This multidisciplinary, population-based case-control study will involve personal interviews to collect information on demographics, residential history, pesticide use, and occupational exposures; self-administered questionnaires to collect information on diet, family and medical history, and other exposures; tap water and carpet dust sampling to collect information on nitrate and pesticide exposures; and blood sampling for measurements of compounds in the serum, antibodies to viruses, and examination of genetic polymorphisms.

Key facts

Study ID

NCT00341952

Run by

National Cancer Institute (NCI)

People needed

2378

Starts

1998-04-15

Expected to finish

2007-04-17

Last updated by the study team

2020-11-27

Who can join

Age: 20 and older, up to 74. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Individuals must not be previously diagnosed with NHL.

Where it is running

• University of Southern California — Los Angeles, California, United States
• University of Iowa — Iowa City, Iowa, United States
• Wayne State University Hutzel Hospital — Detroit, Michigan, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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