Postpartum Uterine Regression
Completed
Conditions studied: Uterine Leiomyoma
In brief
Uterine leiomyomas are the leading cause of hysterectomy in the United States, accounting for over 200,000 procedures each year. Most epidemiologic studies of uterine leiomyoma show that parity has a protective association with leiomyoma, but the mechanism is not known. Both epidemiologic data and data from an animal model indicate that the protective association is not an artifact resulting from reduced fertility among women with fibroids. We hypothesize that the process of uterine regression following delivery results in loss of small fibroids due to selective apoptosis of transformed cells and the extensive remodeling of the entire uterus.
Key facts
- Study ID
- NCT00341848
- Run by
- National Institute of Environmental Health Sciences (NIEHS)
- People needed
- 374
- Starts
- 2001-12-06
- Expected to finish
- 2019-06-13
- Last updated by the study team
- 2019-06-17
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
Where it is running
- NIEHS, Research Triangle Park — Research Triangle Park, North Carolina, United States
Full record on ClinicalTrials.gov
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