Genetic Analysis of Psoriasis and Psoriatic Arthritis

Completed

Conditions studied: Psoriasis

In brief

This study will examine the genetic basis of psoriasis and psoriatic arthritis. It is known that genes play an important role in determining who gets psoriasis or psoriatic arthritis. This study will look for specific gene variants (alleles) that run in families with these conditions, or are found more often in people with these conditions than in those without them. Participants for this study were identified through the dermatology services of the University of Michigan Medical Center, the Ann Arbor Veterans Affairs Medical Center, the University of Kiel, and Henry Ford Hospital. Additional families were provided by the National Psoriasis Foundation Tissue Bank. They include people with psoriasis or psoriatic arthritis, or both, in addition to some family members of patients. Only families in which the age of the patient at disease onset was below 40 years are included. Patients were included if they had lesions covering more than 1 percent of their total body surface area or if at least two skin, scalp, nail, or joint lesions were diagnosed as psoriasis. Healthy volunteers are also enrolled as control subjects. Participants undergo the following procedures, as follows: Patients with psoriasis and people without psoriasis who have multiple family members with the disease * Skin evaluation * Photographs of lesions for documentation Patients with psoriatic arthritis and people without psoriatic arthritis who have multiple family members with the disease * Joint evaluation and possibly ultrasound * Joint X-rays or review of existing X-rays Patients with psoriasis only, with psoriatic arthritis, and healthy volunteers * Blood draw of 30 milliliters. Some of the blood collected will be used to test for rheumatoid factor and C-reactive protein in patients with psoriatic arthritis. * Periodic questionnaires to update health status information

Key facts

Study ID
NCT00341809
Run by
National Cancer Institute (NCI)
People needed
2653
Starts
2004-07-30
Expected to finish
2012-09-04
Last updated by the study team
2018-04-05

Who can join

Age: 1 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.