The Second Multicenter Hemophilia Cohort Study

Completed

Conditions studied: Liver Decompensation, Hepatocellular Carcinoma, Non-Hodgkin Lymphoma

In brief

The Second Multicenter Hemophilia Cohort Study (MHCS-II) will evaluate and prospectively follow approximately 4500 persons with hemophilia who were exposed to hepatitis C virus (HCV). The vast majority will have been infected with HCV, and approximately 1/3 will have been infected with human immunodeficiency virus (HIV). Primary objectives are to quantify the rates of liver decompensation, hepatocellular carcinoma, and non-Hodgkin lymphoma and to evaluate candidate clinical, genetic, virologic, serologic and immunologic markers that are likely to be on the causal pathway for these conditions. Candidate clinical and laboratory markers will be examined longitudinally to define changes over time and their relationships to one another. Collaborative studies will focus on genome scanning and evaluation of candidate genetic loci for susceptibility or resistance to HCV and HIV infections or to the diseases that result from these infections. Additional studies will identify response and complication rates of various anti-HCV and anti-HIV regimens in the setting of comprehensive clinical care of persons with hemophilia.

Key facts

Study ID

NCT00341705

Run by

National Cancer Institute (NCI)

People needed

2565

Starts

2001-04-27

Expected to finish

2013-04-02

Last updated by the study team

2019-12-17

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Is not a patient with an inherited coagulation disorder.
• Does not have a positive test for HCV antibodies, HIV antibodies, or HIV RNA on a licensed assay performed since January 1, 1993.
• Is less than 13 years of age.
• Lacks informed consent/assent.

Where it is running

• University of Arizona — Tucson, Arizona, United States
• University of California, Davis — Davis, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• University of California, San Francisco — San Francisco, California, United States
• University of Colorado — Denver, Colorado, United States
• Christiana Hospital — Wilmington, Delaware, United States
• Georgetown University — Washington D.C., District of Columbia, United States
• Childrens National Medical Center — Washington D.C., District of Columbia, United States
• Emory University — Atlanta, Georgia, United States
• University of Illinois — Chicago, Illinois, United States
• Childrens Memorial Hospital, Chicago — Chicago, Illinois, United States
• St. Vincent's Hospital — Indianapolis, Indiana, United States
• Tulane University — New Orleans, Louisiana, United States
• Wayne State University Hutzel Hospital — Detroit, Michigan, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• University of Mississippi — Jackson, Mississippi, United States
• St. Louis University — St Louis, Missouri, United States
• University of New Mexico — Albuquerque, New Mexico, United States
• University of Buffalo — Buffalo, New York, United States
• North Shore Long Island Jewish Health System — Lake Success, New York, United States
• Cornell University — New York, New York, United States
• Mt. Sinai Medical Center — New York, New York, United States
• University of North Carolina — Chapel Hill, North Carolina, United States
• Wake Forest University — Winston-Salem, North Carolina, United States
• Childrens Hospital, Cinncinati — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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