Family Myopia Study
Completed
Conditions studied: Myopia
In brief
This study will try to identify the gene or genes responsible for myopia (nearsightedness) and to examine the relationship between myopia and near work. Myopia is the most common eye disorder in the world, affecting one in four Americans. Several studies indicate that myopia is inherited. The condition tends to cluster in families, so that studying families with this condition may facilitate finding the exact cause. Caucasian Americans and African Americans with myopia who are in general good health may be eligible for this study. People with a family history of myopia through several generations along one parent s side only, and in which more than one sibling has myopia are preferred. People who have severe diseases that involve myopia, such as Stickler s or Marfan syndromes, retinitis pigmentosa or diabetic retinopathy may not participate. Participants will undergo the following tests and procedures: * Eye examination, including refraction * Blood draw for genetic studies and possibly establishment of cell lines (collection of cells grown in the laboratory from an original tissue specimen) for future research * Myopia Family Study Questionnaire and personal medical information questionnaire to provide information about other medical conditions that may influence the development of myopia; the vision status of their spouse and children, parents and siblings, and spouse s parents and siblings * Risk Factor Questionnaire (for Jewish Orthodox community only) to assess the amount of near work activity done in childhood
Key facts
- Study ID
- NCT00341549
- Run by
- National Human Genome Research Institute (NHGRI)
- People needed
- 7477
- Starts
- 2002-04-29
- Expected to finish
- 2020-03-12
- Last updated by the study team
- 2020-03-13
Who can join
Age: 0 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Excluded from the University of Pennsylvania study are those who have severe diseases that involve myopia, such as Stickler s or Marfan syndromes, ocular disease such as Retinitis Pigmentosa, and those with diseases that may secondarily cause myopia such as diabetes or retinopathy of prematurity. Records of eye examinations obtained prior to the onset of systemic or ocular disease will be accepted.
- Individuals who complete the Risk Factor Questionnaire and who state that they were born more than a month prematurely will not be included in the study.
- Individuals who are myopic in one eye and unaffected in the other (ulnilateral myopes) will not be included in the study.
- Individuals who do not sign the Consent Form will be excluded, and families for whom all necessary members do not sign the Consent Form will be excluded.
- No fetuses, pregnant women, prisoners or other institutionalized individuals will be enrolled.
- Generally, myopia itself is not associated with mental impairment, although careful consideration will be given to determining the cognitive understanding of any such potentially impaired person appropriate for enrollment in order to assure that protection of human rights is optimized.
Where it is running
- National Human Genome Research Institute (NHGRI), 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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