A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study

Completed

Conditions studied: Genetics

In brief

Studies have shown that there is a significant association between serum bilirubin concentrations and risk of coronary artery disease (CAD). So far, no linkage analysis in humans between serum bilirubin and DNA markers has been reported. The purpose of this protocol is to identify chromosome regions that contain quantitative trait loci (QTL) involved in serum bilirubin metabolism and bilirubin concentration. In the Framingham Study, a 10cM genome scan (about 400 markers) has been conducted in more than three hundred families. Serum bilirubin was measured in the first and second exams of the Framingham Offspring. These data provide us the opportunity to undertake linkage analyses to map QTL of serum bilirubin.

Key facts

Study ID
NCT00340509
Run by
National Heart, Lung, and Blood Institute (NHLBI)
People needed
1888
Starts
2001-10-26
Expected to finish
2013-07-23
Last updated by the study team
2019-12-16

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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