Effect of Brain Lesion Severity on Treatment Response in Late-Life Depression

Completed · Not applicable

Conditions studied: Depression

In brief

This study will determine the relationship between brain lesion severity, treatment response, and frontal lobe brain function in people with late-life depression (LLD).

Key facts

Study ID

NCT00339066

Run by

Duke University

People needed

131

Starts

2001-08-01

Expected to finish

2006-03-01

Last updated by the study team

2013-08-09

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• DSM-IV of major depressive disorder (MDD)
• Score of greater than 20 on the MADRS (score of greater than 17 for atypical depression)
• Score of greater than 20 on the Mini Mental State Examination (MMSE)

You may not qualify if…

• Any condition that may make having an MRI medically inadvisable
• Any severe or unstable medical conditions
• Any known primary neurological disorders, including history of stroke
• Any other simultaneous Axis I disorder
• History of substance or alcohol abuse disorder within 6 months prior to study entry
• Currently at risk for suicide
• History of failed prior adequate trials of two antidepressants for the current depressive episode
• History of failed prior adequate trial of sertraline
• Current use of any other psychoactive medications (medication washout will be required)

Where it is running

• Washington University in St. Louis — St Louis, Missouri, United States
• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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