Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy
Completed · Phase 2
Conditions studied: HIV Infections, Depression
In brief
This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally housed people with depression.
Key facts
- Study ID
- NCT00338767
- Run by
- Massachusetts General Hospital
- People needed
- 150
- Starts
- 2001-01-01
- Expected to finish
- 2006-08-01
- Last updated by the study team
- 2013-11-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Homeless or marginally housed
- Score of greater than 13 on the Beck Depression Inventory (BDI)
- DSM-IV diagnosis of major depressive disorder, dysthymia, or minor depressive disorder
- Considered by the reviewing psychiatrist to benefit from antidepressant therapy
- Willing to take antidepressant medication or, if currently taking medication, willing to change medications if deemed appropriate
- Consents to coordinate with the primary medical provider
- Speaks English
You may not qualify if…
- Signs and symptoms consistent with diagnosis of dementia, as defined by DSM-IV
- Current substance abuse disorder requiring immediate residential or inpatient treatment
- At risk for suicide
- Presence of signs and symptoms consistent with psychotic depression, as defined by DSM-IV, warranting immediate hospitalization
- Any condition or use of any medication that may make simultaneous use of antidepressant medication unsafe
- Currently prescribed antidepressant therapy and in psychiatric treatment (treated by a psychiatrist within 3 months prior to study entry)
- Pregnant
- Bipolar disorder
- Current psychotic disorder
Where it is running
- UCSF Market Street Study Site — San Francisco, California, United States
Full record on ClinicalTrials.gov
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