Effect of Exercise and Diet on Inflammation in Hypertensive Individuals
Completed · Not applicable
Conditions studied: Hypertension
In brief
In addition to high blood pressure, hypertension is characterized by inflammation, which is the body's response to injury or infection. Inflammation has been found to cause plaque formation on artery walls. This study will compare the effect of an exercise program versus a combined exercise and diet program on reducing inflammation in hypertensive individuals.
Key facts
- Study ID
- NCT00338572
- Run by
- University of California, San Diego
- People needed
- 185
- Starts
- 2006-06-01
- Expected to finish
- 2012-04-01
- Last updated by the study team
- 2012-06-08
Who can join
Age: 25 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Unmedicated hypertension with blood pressure greater than 140/90 mm Hg but less than 175/104 mm Hg
- Body mass index (BMI) of 23.5 to 34
- Relatively inactive, as defined by the Leisure Time Exercise Questionnaire
- Willing and able to participate in the assigned study group
- Postmenopausal women not on hormone replacement therapy (HRT) and premenopausal women
You may not qualify if…
- Abnormal echocardiogram
- Recent stroke or significant brain impairment
- Current psychiatric disease
- History of psychosis or major depression
- Currently taking psychotropic drugs
- Currently taking any medications (e.g., anti-inflammatory medications) other than antihypertensives (which will be tapered)
- Current drug and/or alcohol abuse
- Consumes more than 600 mg of caffeine per day
- Diabetes
- Congestive heart failure
- Bronchospastic pulmonary disease
- History of heart attacks
- Known secondary high blood pressure
- Angina
- History of life-threatening arrhythmias
- History of kidney damage
- Current participation in regular or structured exercise classes, or regular physical exercise in the 6 months prior to study entry
- Inability to perform moderate to vigorous intensity exercise
- Current participation in a diet
- High blood pressure, only when measured in a doctor's office (i.e., "white coat hypertension")
- Arthritis, exertional asthma, or any other disorder likely to be made worse by exercise
- Pregnant
Where it is running
- University of California, San Diego — San Diego, California, United States
Full record on ClinicalTrials.gov
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