The Effect of Cinacalcet on Gastric Acid Output in Healthy Subjects

Completed · Not applicable

Conditions studied: Healthy

In brief

The purpose of this study is to determine whether cinacalcet will increase gastric acid secretion in healthy volunteers.

Key facts

Study ID

NCT00336739

Run by

Tufts University

People needed

17

Starts

2006-04-01

Expected to finish

2007-03-01

Last updated by the study team

2007-07-23

Who can join

Age: 45 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy ambulatory men and postmenopausal women
• Age 45 to 70
• Avoid alcohol, antacids, H2 blockers, proton pump inhibitors, or antihistamines during the study.

You may not qualify if…

• Ionized Ca++ level <4.39 mg/dl or >5.02 mg/dl (normal reference range 4.18- 5.02).
• 24-hour UCa++ excretion >350 mg.
• Cr >1.3.
• AST/ALT values >10% beyond reference range.
• Hgb level <11.7 g/dl in women and <13.2 g/dl in men.
• MCV level >102 UM3.
• Basal acid output >5 mEq/h in men and >3.8 mEq/h in women.
• Basal acid output <1 mEq/h in men and <0.2 mEq/h in women.
• Age <45 or >70.
• Premenopausal or <1 year post-menopause.
• Individuals following vegan diets.
• Current EtOH abuse.
• Lidocaine allergy. Medications
• Antacids
• H2 blockers
• Proton pump inhibitors
• Carafate
• Anticholinergic agents (i.e. TCA)
• Cholinergic agents
• Antihistamines in the last 3 weeks
• Cogentin
• Adrenergic blockers
• Thiazide diuretics
• Antiplatelet drugs
• Oral and Inhaled Glucocorticoids

Where it is running

• Human Nutrition Research Center on Aging at Tufts University — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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