The Effects of Dexmedetomidine and Remifentanil on Carotid Patients

Stopped early · Phase 4

Conditions studied: Carotid Artery Stenosis

In brief

We propose to test whether intraoperative administration of dexmedetomidine will reduce hemodynamic control in the intra- and post-operative periods and reduces PACU analgesic requirements in patients undergoing carotid endarterectomy.

Key facts

Study ID

NCT00335972

Run by

The Cleveland Clinic

People needed

142

Starts

2006-06-01

Expected to finish

2008-05-01

Last updated by the study team

2017-08-11

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Consenting adult patients (age >50 years) undergoing carotid endarterectomy with general anesthesia.

You may not qualify if…

• Receiving another alpha 2-adrenoreceptor agonist;
• Contraindication to dexmedetomidine, including allergy;
• Current hepatic disease (liver function tests > twice upper limit of normal);
• Renal insufficiency, as defined by a creatinine > 2.0 mg/dL;
• Mentally impairment, including dementia or delirium;
• Heart block ;
• Sick sinus syndrome;
• Atrial fibrillation with a low ventricular response (< 50 bpm);
• Absolute or relative hypovolemia;
• Prior stroke;
• Severe left-ventricular dysfunction

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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