Efficacy of Lansoprazole in Chronic Post Nasal Drip

Completed · Phase 3 · Has a placebo group

Conditions studied: Larynx Disease

In brief

The purpose of this study is to determine whether aggressive acid suppression with Lansoprazole is effective in the treatment of post nasal drip, and also assess the predictors of response based on clinical and physiologic parameters.

Key facts

Study ID

NCT00335283

Run by

Vanderbilt University

People needed

75

Starts

2006-08-01

Expected to finish

2008-12-01

Last updated by the study team

2012-08-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Negative RAST inhalant allergy panel OR negative skin testing (Group A)
• Positive RAST or Positive skin testing AND insufficient response to all of the following: (Group B)
• Allergen avoidance
• Topical nasal steroids
• Allergy shots if indicated
• Antihistamines
• Negative CT sinuses (coronal)
• < 4mm of mucosal thickening and < 3 sinus sites
• Absence of air-fluid levels
• Negative anterior rhinoscopy
• Absence of pus, crusts on mucosal surfaces

You may not qualify if…

• Age < 18
• Pregnancy, confirmed by urine pregnancy test at day of randomization
• Ciliary dyskinesia
• Immune deficiency
• Cystic fibrosis
• Diagnosis of acute sinusitis or chronic RS (AAO-HNS)
• Active use of topical decongestant
• Use of PPI within the last 30 days
• Previous fundoplication
• Uncontrolled thyroid disease
• Isolated chronic cough without the symptom of post nasal drip

Where it is running

• Vanderbilt University Medical Center, Vanderbilt Digestive Disease Clinic, TVC, Room 1660 — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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