A Study of MSI-1256F (Squalamine Lactate) To Treat "Wet" Age-Related Macular Degeneration
Stopped early · Phase 2
Conditions studied: Macular Degeneration
In brief
Age-Related Macular Degeneration (AMD) is a degenerative eye disease of the retina that causes a progressive loss of central vision. AMD is the leading cause of legal blindness among adults age 50 or older in the Western world. AMD presents in two different types - "dry" and the more severe "wet" form. Wet AMD is caused by the growth of abnormal blood vessels in the macula. Squalamine lactate is an investigational drug that may prevent the growth of these abnormal blood vessels. This study will test the safety and efficacy of Squalamine in the treatment of AMD.
Key facts
- Study ID
- NCT00333476
- Run by
- Genaera Corporation
- People needed
- 140
- Starts
- 2006-05-01
- Last updated by the study team
- 2007-11-28
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult subjects ≥ 50 years of age.
- minimally classic or active occult choroidal neovascularization associated with age-related macular degeneration in one or both eyes.
- baseline best corrected visual acuity score between 35 to 65 letters according to the Early Treatment of Diabetic Retinopathy Study protocol.
- central retinal thickness by optical coherence tomography of > 250 microns.
- lesions > 9 disc areas.
- > 25% fibrosis in the lesion.
You may not qualify if…
- Previous history of triamcinolone, bevacizumab, ranibizumab, or pegaptanib sodium injection therapy in the study eye.
- retinal or optic nerve disease.
- uncontrolled diabetes.
- ongoing malignancy.
Where it is running
- Florida Eye Microsurgical Institute — Boynton Beach, Florida, United States
- Retina Health Center — Fort Meyers, Florida, United States
- Bascom Palmer Eye Institute — Miami, Florida, United States
- Midwest Eye Institute — Indianapolis, Indiana, United States
- Retina Specialists — Towson, Maryland, United States
- Eye Foundation of Kansas City — Kansas City, Missouri, United States
- Ophthalmic Consultants of Long Island — Long Island City, New York, United States
- Retina Associates of Western New York — Rochester, New York, United States
- Charles Garcia, MD, P.A. — Houston, Texas, United States
Full record on ClinicalTrials.gov
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