Determining Optimal Continuation Treatment Duration for Depressed Children and Adolescents

Completed · Not applicable

Conditions studied: Depression

In brief

This study will determine the optimal length of continuation treatment with fluoxetine for children and adolescents with major depressive disorder, as well as the factors that may contribute to positive response during acute and continuation treatment.

Key facts

Study ID

NCT00332787

Run by

University of Texas Southwestern Medical Center

People needed

200

Starts

2000-06-01

Expected to finish

2005-10-01

Last updated by the study team

2014-01-08

Who can join

Age: 7 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Currently being treated on an outpatient basis
• Currently attending school
• Diagnosis of non-psychotic major depressive disorder (MDD)
• Duration of illness is at least 4 weeks
• In good general medical health
• Normal intelligence

You may not qualify if…

• Lifetime history of any psychotic disorder, including psychotic depression
• Diagnosis of bipolar I or II disorder
• History of alcohol or substance abuse or dependence within 6 months of study entry
• Lifetime history of anorexia nervosa or bulimia
• Pregnant or breastfeeding
• Does not agree to use an effective form of contraception (i.e., IUD, birth control pills, or barrier devices)
• Any chronic medical illness requiring regular medication
• Currently taking medication with psychotropic effects (i.e., anticonvulsants, steroids, etc.), other than stable stimulant treatment
• A first degree relative has bipolar I disorder
• Previous adequate treatment with fluoxetine was ineffective (defined as at least 20 mg/day for 4 weeks)

Where it is running

• Children's Medical Center at Dallas, Outpatient Psychiatry Clinic — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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