A Phase I Study of BMS-275183 (Oral Taxane) Given on a Daily Schedule in Combination With Esomeprazole (Nexium) in Patients With Advanced Cancer

Stopped early · Phase 1

Conditions studied: Cancer

In brief

The purpose of this study is to determine what effects Esomeprazole (Nexium) has on increasing or decreasing the amount of oral taxane in the blood, and to determine the safety of oral taxane and effect of oral taxane on the cancer.

Key facts

Study ID

NCT00332748

Run by

Bristol-Myers Squibb

People needed

36

Starts

2006-12-01

Last updated by the study team

2010-03-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Advanced cancers excluding cancers within the blood
• Adequate kidney and liver function
• > = 4 weeks from last course of chemotherapy

You may not qualify if…

• Inability to swallow capsules
• Other active medical disorder
• Abnormal heart function or use of drugs that affect the heart

Where it is running

• Local Institution — Newark, Delaware, United States
• Local Institution — Louisville, Kentucky, United States
• Local Institution — Las Vegas, Nevada, United States
• Local Institution — Amsterdam, Netherlands

Full record on ClinicalTrials.gov

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