Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms

Completed · Phase 4 · Has a placebo group

Conditions studied: Nicotine Dependence

In brief

The proposed work will advance the understanding and effectiveness of tobacco dependence treatment and result in more smokers quitting successfully.

Key facts

Study ID

NCT00332644

Run by

University of Wisconsin, Madison

People needed

1504

Starts

2004-09-01

Expected to finish

2010-08-01

Last updated by the study team

2011-11-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Smoke at least 10 cigarettes per day for the previous 6 months - Expired CO > 9 ppm - Motivated to quit smoking - Able to read and write English - Willing to complete required study assessments

You may not qualify if…

• Uncontrolled hypertension (systolic >180mm Hg or diastolic >110mm Hg) - History of bipolar disorder or psychosis - Myocardial infarction or other serious cardiac problem in the previous 4 weeks - History of diagnosed anorexia and/or bulimia - Diagnosis of Alcohol Dependence in the previous 6 months by participant self-report or drinking 6 or more drinks on six or more days a week - History of seizure and/or serious head injury involving loss of consciousness - Use of contraindicated medications (MAO inhibitors, bupropion, lithium, anticonvulsants, antipsychotics) - Currently pregnant or breast-feeding - Unwilling to use effective contraception during the treatment phase - More than one participant from the same household - Allergic reactions to 3 or more classes of drugs

Where it is running

• UW-CTRI Madison Research site — Madison, Wisconsin, United States
• UW-CTRI Milwaukee Research site — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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