Mechanisms of Insulin Resistance in Humans

Completed

Conditions studied: Inflammation, Insulin Resistance

In brief

The Objectives of the study are to: (1)compare the inflammatory response and insulin resistance in skeletal muscles during a systemic infusion of lipid with that during a local infusion of lipid into the femoral artery. which would cause minimal or no systemic hyperlipidemia but local plasma free fatty acid (FFA) concentrations similar to those during the systemic lipid infusion, and (2) determine the inflammatory response and insulin resistance in skeletal muscle during an infusion of lipid into the femoral artery as described above after NF-KB inhibition by high dose salicylate treatment in humans.

Key facts

Study ID

NCT00330967

Run by

US Department of Veterans Affairs

People needed

25

Starts

2006-04-01

Expected to finish

2014-08-01

Last updated by the study team

2015-04-03

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• two groups of 16 healthy subjects

You may not qualify if…

• diabetes or impaired glucose tolerance
• peripheral vascular disease
• pulmonary disease
• clinically significant hepatic or renal disease
• triglycerides >200mg/dl
• anemia
• abnormal PT, PTT or INR
• pregnancy or lactation

Where it is running

• Phoenix VA Health Care System Carl T. Hayden VA Medical Center, Phoenix, AZ — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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