Serial Exhaled Breath pH Monitoring

Status unconfirmed

Conditions studied: Gastroesophageal Reflux

In brief

This study will seek to determine the amount of acids a person with a chronic cough that is suspected to be related to acid reflux breathes out after coughing. The study will also seek to determine if this measurement can predict the best treatment for the cough. Subjects with a chronic cough which is suspected to be related to acid reflux for which their doctor has prescribed a proton pump inhibitor medication will be enrolled in this study.

Key facts

Study ID

NCT00330603

Run by

University of Virginia

People needed

99

Starts

2006-04-01

Expected to finish

2011-12-01

Last updated by the study team

2011-03-08

Who can join

Age: 5 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Outpatient
• 5 years of age and older
• Cough lasting a minimum of 3 weeks
• Has been prescribed a proton pump inhibitor as a single therapeutic and diagnostic effort to control the cough

You may not qualify if…

• Inability to perform serial exhaled breath condensate collections at home
• Unwillingness to initiate proton pump inhibitor therapy as prescribed by physician
• Other changes planned in therapy, such as initiating or discontinuing cough suppressant therapy, initiating or augmenting antibiotic therapy, initiating or augmenting anti-inflammatory therapy
• Previous treatment of respiratory symptoms with proton pump inhibitor therapy
• Current treatment with angiotensin converting enzyme inhibitor medication or H2 antagonists
• Regular exposure to an environmental irritant

Where it is running

• University of Virginia — Charlottesville, Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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